Record Details

Significance of Salivary miRNA 21 Determined by Real Time PCR in Patients with Squamous Cell Carcinoma

Journal of Baghdad College of Dentistry


Field	Value

Title	Significance of Salivary miRNA 21 Determined by Real Time PCR in Patients with Squamous Cell Carcinoma

Creator	Edan, Wisam Hamid El-Samarrai, Sulafa Khalid

Description	Background: Salivary biomarkers, a non-invasive alternative method to serum and tissue based biomarkers and it is consider as an effective modality for early diagnosis. Salivary microRNA 21, a nucleotide biomarker, was reported to increase in patients with oral squamous cell carcinoma. This study was conducted to measure the fold change of microRNA 21 in stimulated saliva and to study its association with smoking and occurrence of oral squamous cell carcinoma. Materials and methods: A 20 patients with oral squamous cell carcinoma who used to be smokers was included in addition to 40 control subjects (20 smokers and 20 non- smokers health looking subjects). Stimulated saliva was collected under standardized condition. Salivary microRNA 21 was assessed by real time PCR. Results: MicroRNA 21 fold change was significantly higher in both smoker patients with oral squamous cell carcinoma and in smoker control subjects compared to non-smoker control subjects. Conclusions: Salivary micrRNA21 can serve as a non-invasive tool aid in the diagnosis and follow up of squamous cell carcinoma patients.

Publisher	College of dentistry/ University of baghdad

Date	2016-09-14

Type	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Peer-reviewed Article

Format	application/pdf

Identifier	http://jbcd.uobaghdad.edu.iq/index.php/jbcd/article/view/1447 10.12816/0031128

Source	Journal of Baghdad College of Dentistry; Vol 28 No 3 (2016); 178-180 2311-5270 1680-0087

Language	eng

Relation	http://jbcd.uobaghdad.edu.iq/index.php/jbcd/article/view/1447/pdf

Rights	Copyright (c) 2016 Journal of Baghdad College of Dentistry