In vivo immunohistochemical investegation of bone deposition at collagen coated Ti implant surface
Journal of Baghdad College of Dentistry
View Archive Info| Field | Value | |
| Title |
In vivo immunohistochemical investegation of bone deposition at collagen coated Ti implant surface
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| Creator |
Al Ghani, Ban A.
Al Hijazi, Athraa Y. AL Zubaydi, Thair L. |
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| Description |
Background: Dental implants provide a unique treatment modality for the replacement of lost dentition. Functional surface modifications by organic material such as collagen coating seem to enhance early peri-implant bone formation, enhancing the initial cell attachment. The aim of the study was to study the expression of osteocalcin and growth hormone receptor as bone formation markers in collagen coated and uncoated implant in interval periods(2,and 6 weeks). Materials and Methods: Commercially pure Titanium(cpTi) implants, coated with collagen protein, were placed in the tibias of 32 New Zealand white rabbits, immunohistochemical tests for detection of expression of osteocalcin and growth hormone receptor were performed on all the implants of both control and experimental groups for (2, and 6 weeks) healing intervals. Mechanical test (torque removal test) was performed as an indicator for the presence of osseointegration and as a test for the mechanical property of bone-implant interface, because the torsion appears to be primarily probing the interface mechanics. Results: Removal torque mean values in all studied groups (uncoated and coated with collagen at two and six healing intervals were increasing with advancing time (higher at 6 than 2 weeks periods). And coated implant showed high value in comparison to control. Results have shown that positive reaction for OC&GHR was expressed by osteoblast cells (OB)at implants coated with collagen ,indicating that bone formation &maturation was accelerated by adding biological materials as a modification modality of implant surface.. Conclusion: Immunohistochemical findings revealed high positive expression range from strong to moderate of osteocalcin and GHR in coated implant in comparison to uncoated specialy in early periods. |
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| Publisher |
College of dentistry/ University of baghdad
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| Date |
2017-01-30
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| Type |
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion Peer-reviewed Article |
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| Identifier |
http://jbcd.uobaghdad.edu.iq/index.php/jbcd/article/view/1564
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| Source |
Journal of Baghdad College of Dentistry; Vol 23 No Special Is (2011); 47-52
2311-5270 1680-0087 |
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| Language |
en
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| Rights |
Copyright (c) 2017 Journal of Baghdad College of Dentistry
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