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Biochemical Risk Determinants of Osteoporosis in Overweight and Obese Postmenopausal Women with Type 2 Diabetes Mellitus

AL-Kindy College Medical Journal

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Title Biochemical Risk Determinants of Osteoporosis in Overweight and Obese Postmenopausal Women with Type 2 Diabetes Mellitus
 
Creator . Ibrahem, Ikhlass H
 
Description Background: Several studies suggested that skeletal system is adversely affected by diabetes and is associated with increased risk of osteoporosis and fragility fractures  
Objectives: The study was a case-control study that designed to assess the level of bone turnover markers (BTMs) among patients with type 2 diabetes mellitus (T2DM) and to investigate the effect of body weight and diabetic control on the level of bone turnover
Type of the study: Cross- sectional study.
Methods: The present study included 100 postmenopausal women with type 2 diabetes mellitus. Sixty-six non-diabetic postmenopausal women were enrolled as a control. Fasting blood samples were collected to measure Alkaline phosphatase (ALP),stoeocalcin(OC), fasting blood sugar (FBS)and glycated hemoglobin (HbA1c). Urine samples were collected to measure deoxypyridinolin(DPD). The results were expressed as a ratio to urine creatinine
Results: The mean level of serum osteocalcin was significantly lower in the diabetic group than in the control group,while the level of urinary deoxypyridinolin was significantly higher in the diabetic group than in the control group . There was no significant difference in the level of Alkaline phosphatase between diabetic patients and control. An inverse association was found between osteocalcin with body mass index(BMI), glycated hemoglobin and fasting blood sugar. On the other hand appositive association was found between the level of deoxypyridinolin with body mass index
Conclusions: Altered bone metabolic markers in patients with T2DM with more significant alterations in those who hsd poor glycemic control . Decrease in formation marker osteocalcin and increased resorption markers such as (DPD) has been found.
 
 
Publisher AL-Kindy College Medical Journal
 
Date 2018-10-21
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
 
Format application/pdf
 
Identifier http://jkmc.uobaghdad.edu.iq/index.php/MEDICAL/article/view/15
 
Source مجلة كلية طب الكندي; مجلد 14 عدد 1 (2018): AL-KINDY COLLEGE MEDICAL JOURNAL; 33-36
AL-Kindy College Medical Journal; Vol 14 No 1 (2018): AL-KINDY COLLEGE MEDICAL JOURNAL; 33-36
2521-4365
1810-9543
 
Language eng
 
Relation http://jkmc.uobaghdad.edu.iq/index.php/MEDICAL/article/view/15/11
 
Rights Copyright (c) 2018 AL-Kindy College Medical Journal