Record Details

Studying of the complexes product of the nerve agent Soman with the Butyrylcholinesterase and Acetylcholinesterase Enzymes

Baghdad Science Journal


Field	Value

Title	Studying of the complexes product of the nerve agent Soman with the Butyrylcholinesterase and Acetylcholinesterase Enzymes

Creator	Journal, Baghdad Science

Description	Cholinesterases are among the most efficient enzymes known. They are divided into two groups: acetylcholinesterase (AChE) involved in the hydrolysis of the neurotransimitter acetylcholine, and butyrylcholinesterase (BChE) of unknown function. Several crystal structures of the former have shown that the active site is located at the bottom of a deep and narrow gorge. Human BChE has attracted attention because it can hydrolyze toxic esters and nerve agents. Here we analyze the complexes of cholinesterase with soman by describing the 3D geometry of the complex, the active site, the changes happened through the inhibition and provide a description for the mechanism of inhibition. Soman undergoes degradation in the active site of the AChE and BChE. We calculate the energy of the products of the degradation reaction and suggest the reaction path. The product of the former reaction bind to serine residue in the active site and forming a stable bond and ends the catalytic function of the enzyme. This study has a useful role in the search of inhibitors to help in the treatment of Alzahimer's disease.

Publisher	College of Science for Women - University of Baghdad

Date	2008-06-01

Type	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Peer-reviewed Article

Format	application/pdf

Identifier	http://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/900

Source	مجلة بغداد للعلوم; مجلد 5 عدد 2 (2008): issue 2; 297-304 Baghdad Science Journal; Vol 5 No 2 (2008): issue 2; 297-304 2411-7986 2078-8665

Language	eng

Relation	http://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/900/831

Rights	Copyright (c) 2008 Baghdad Science Journal