Spectrophotometric micro determination of drug promethazine hydrochloride in some pharmaceutical by chelating with Rhodium
Baghdad Science Journal
View Archive Info| Field | Value | |
| Title |
Spectrophotometric micro determination of drug promethazine hydrochloride in some pharmaceutical by chelating with Rhodium
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| Creator |
Journal, Baghdad Science
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| Description |
The drug promethazine hydrochloride (PRZH) forms with rhodium (II) a colored chelate (?max = 472 nm) complex at (pH = 2.1) which is extractable with benzyl alcohol as organic solvent. Under the appropriate experimental conditions a calibration plot was set up from which some analytical parameter were derived and deduced by regression. Standard addition procedure was also adopted. It has been estimated that the concentration of the drug PRZH to be 24.89 mg per unit and 24.19 mg per unit for both calibrations. Under optimal conditions, the developed method has been achieved the following characteristics: LDR (30 – 150 µg ml-1 ) PRZH , RSD % ( 0.6 – 2.47 ) , sandell sensitivity( 0.0844 µg. cm -2 ) , LOD ( 1.66 µgml-1 ) , recovery % ( 100.74 ± 1.34 ) , Erel % ( 0.74 ) . Stability constant (6.4 × 10 5 M-1). The mole – ratio method (1: 1) approved that PRZH – Rh (II) as a structure of the complex. The developed procedure has been adapted to analyze PRZH in various pharmaceuticals. |
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| Publisher |
College of Science for Women - University of Baghdad
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| Date |
2008-12-07
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| Type |
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion Peer-reviewed Article |
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| Format |
application/pdf
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| Identifier |
http://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/945
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| Source |
مجلة بغداد للعلوم; مجلد 5 عدد 4 (2008): issue 4; 638-645
Baghdad Science Journal; Vol 5 No 4 (2008): issue 4; 638-645 2411-7986 2078-8665 |
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| Language |
eng
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| Relation |
http://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/945/876
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| Rights |
Copyright (c) 2008 Baghdad Science Journal
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