Record Details

High performance liquid chromatographic method for the determination of guaifenesin in pharmaceutical syrups and in environmental samples

Baghdad Science Journal


Field	Value

Title	High performance liquid chromatographic method for the determination of guaifenesin in pharmaceutical syrups and in environmental samples

Creator	Journal, Baghdad Science

Description	A simple, precise, rapid, and accurate reversed – phase high performance liquid chromatographic method has been developed for the determination of guaifenesin in pure from pharmaceutical formulations.andindustrial effluent. Chromatography was carried out on supelco L7 reversed- phase column (25cm × 4.6mm), 5 microns, using a mixture of methanol –acetonitrile-water: (80: 10 :10 v/v/v) as a mobile phase at a flow rate of 1.0 ml.min-1. Detection was performed at 254nm at ambient temperature. The retention time for guaifenesin was found 2.4 minutes. The calibration curve was linear (r= 0.9998) over a concentration range from 0.08 to 0.8mg/ml. Limit of detection (LOD) and limit of quantification ( LOQ) were found 6µg/ml and 18µg/ml respectively. The method was validated for its linearity, precision and accuracy .The proposed method was successfully applied for the determination of guaifenesin in syrups and industrial effluent samples.

Publisher	College of Science for Women - University of Baghdad

Date	2013-09-01

Type	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Peer-reviewed Article

Format	application/pdf

Identifier	http://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/2612

Source	مجلة بغداد للعلوم; مجلد 10 عدد 3 (2013): issue 3 المؤتمر الوطني الاول لقسم علوم الكيمياء; 1014-1022 Baghdad Science Journal; Vol 10 No 3 (2013): issue 3 المؤتمر الوطني الاول لقسم علوم الكيمياء; 1014-1022 2411-7986 2078-8665

Language	eng

Relation	http://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/2612/2543

Rights	Copyright (c) 2013 Baghdad Science Journal