Record Details

Kinetic Study of the Hydrolysis of synthesized Ibuprofen Ester and its Biological Activity

Baghdad Science Journal


Field	Value

Title	Kinetic Study of the Hydrolysis of synthesized Ibuprofen Ester and its Biological Activity

Creator	Journal, Baghdad Science

Description	It is known that the oral administration of ibuprofen caused an irritation of stomach as a side effect due to its carboxylic moiety. Ibuprofen ester was synthesized by linking the carboxylic moiety of ibuprofen and the hydroxylic group of paracetamol to reduce its side effect. Study the kinetic hydrolysis of prepared ester was examined at different values of physiological pH (1.0, 5.8, 6.4 and 7.4) at 37 ± 0.1 of 1 hour period. Measurements of absorbance were carried out by UV-Visible spectrophotometer to follow the stability of ester, it showed Pseudo first order hydrolysis. The pH- apparent rate profiles of ester was exhibited a good stability at pH 1.0 and pH 5.8. Pharmacological activity in vivo of prepared ester was evaluated in relation to analgesic and anti-inflammatory activity using the acetic acid method and the hind paw oedema inhibition, respectively. Acetyl salicylic acid (aspirin) was used as a reference drug for the above tests. The synthesized ester showed higher analgesic and anti-inflammatory action than aspirin.

Publisher	College of Science for Women - University of Baghdad

Date	2013-09-01

Type	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Peer-reviewed Article

Format	application/pdf

Identifier	http://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/2618

Source	مجلة بغداد للعلوم; مجلد 10 عدد 3 (2013): issue 3 المؤتمر الوطني الاول لقسم علوم الكيمياء; 1062-1070 Baghdad Science Journal; Vol 10 No 3 (2013): issue 3 المؤتمر الوطني الاول لقسم علوم الكيمياء; 1062-1070 2411-7986 2078-8665

Language	eng

Relation	http://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/2618/2549

Rights	Copyright (c) 2013 Baghdad Science Journal