Biodegradation Studies in Vitro of Novel Poly(adipic anhydride-co-mannitol)-N-maleoyl Chitosan Networks
Baghdad Science Journal
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| Title |
Biodegradation Studies in Vitro of Novel Poly(adipic anhydride-co-mannitol)-N-maleoyl Chitosan Networks
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| Creator |
Journal, Baghdad Science
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| Description |
In this work, novel copolymers of poly(adipic anhydride-co-mannitol) were synthesized by melting condensation polymerization of poly(adipic anhydride) with five percentages of mannitol sugar, 1 to 5 Wt.%. These copolymers were purified and then, characterized by FT-IR, which was proved that the cross-linking reaction was caused by nucleophilic attack of mannitol hydroxyl group to acidic anhydride groups of poly(adipic anhydride) backbone and new ester groups were formed and appeared. Also, modified organic-soluble chitosan, N-maleoyl-chitosan, were synthesized by grafting reaction of chitosan with maleic anhydride in DMF as solvent, and it was also purified and characterized by FT-IR. Biodegradation in vitro of the IPNs of poly(adipic anhydride-co-mannitol)-N-maleoyl chitosan networks were evaluated by hydrolytic degradation studies at three different media (PBS, SIF and SGF) for 18 weeks with 92% as maximum degradation and it was found that minimum weight loss of IPNs was noticeably shown in SIF. In addition, hydrolytic degradation percent was decreased with increasing mannitol proportions.
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| Publisher |
College of Science for Women - University of Baghdad
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| Date |
2016-06-05
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| Type |
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion Peer-reviewed Article |
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| Format |
application/pdf
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| Identifier |
http://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/2767
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| Source |
مجلة بغداد للعلوم; مجلد 13 عدد 2 (2016): issue 2 المؤتمر الوطني الثاني لقسم علوم الكيمياء; 210-220
Baghdad Science Journal; Vol 13 No 2 (2016): issue 2 المؤتمر الوطني الثاني لقسم علوم الكيمياء; 210-220 2411-7986 2078-8665 |
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| Language |
eng
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| Relation |
http://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/2767/2698
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| Rights |
Copyright (c) 2016 Baghdad Science Journal
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