The Spectrophotometric Determination of Olanzapine via Coupling with Diazotized p-Nitroaniline
Iraqi Journal of Pharmaceutical Sciences
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| Title |
The Spectrophotometric Determination of Olanzapine via Coupling with Diazotized p-Nitroaniline
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| Creator |
R. Fadhel, Sahar
I. Abdulla, Najwa D. Sulaiman, Intidhar |
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| Description |
A new spectrophotometric method has been developed for the assay of olanzapine (OLN.) in pure and dosage forms. The method is based on the diazocoupling of (OLN.) with diazotized p-nitroaniline in alkaline medium to form a stable brown colored water-soluble azo dye with a maximum absorption at 405 nm. The variables that affect the completion of reaction have been carefully optimized. Beer’s law is obeyed over the concentration range of (0.5-45.0 μg.mL-1) with a molar absorptivity of 1.5777×104 L.mol-1.cm-1. The limit of detection was 0.3148 μg.mL-1 and Sandell’s sensitivity value was 0.0198 μg.cm-2. The proposed method has been applied successfully to the determination of olanzapine in tablet pharmaceutical preparations. Keywords: Spectrophotometry, Olanzapine, Diazotization, p-nitroaniline, tablet dosage form. |
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| Publisher |
University of Baghdad- College of Pharmacy
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| Date |
2017-03-26
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| Type |
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion |
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| Format |
application/pdf
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| Identifier |
http://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/359
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| Source |
Iraqi Journal of Pharmaceutical Sciences ( P-ISSN: 1683 - 3597 , E-ISSN : 2521 - 3512); Vol 25 No 1 (2016): Iraqi J Pharm Sci, Vol.25(1) 2016; 42-49
1683-3597 2521-3512 |
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| Language |
eng
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| Relation |
http://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/359/293
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| Rights |
Copyright (c) 2017 Iraqi Journal of Pharmaceutical Sciences
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