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The Spectrophotometric Determination of Olanzapine via Coupling with Diazotized p-Nitroaniline

Iraqi Journal of Pharmaceutical Sciences

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Title The Spectrophotometric Determination of Olanzapine via Coupling with Diazotized p-Nitroaniline
 
Creator R. Fadhel, Sahar
I. Abdulla, Najwa
D. Sulaiman, Intidhar
 
Description A new spectrophotometric method has been developed for the assay of olanzapine (OLN.) in pure and dosage forms. The method is based on the diazocoupling of (OLN.) with diazotized p-nitroaniline in alkaline medium to form a stable brown colored water-soluble azo dye with a maximum absorption at 405 nm.  The variables that affect the completion of reaction have been carefully optimized. Beer’s law is obeyed over the concentration range of (0.5-45.0 μg.mL-1) with a molar absorptivity of 1.5777×104 L.mol-1.cm-1.  The limit of detection was  0.3148  Î¼g.mL-1 and  Sandell’s  sensitivity value was 0.0198 μg.cm-2. The proposed method has been applied successfully to the determination of olanzapine in tablet pharmaceutical preparations.
Keywords: Spectrophotometry, Olanzapine, Diazotization, p-nitroaniline, tablet dosage form. 
 
Publisher University of Baghdad- College of Pharmacy
 
Date 2017-03-26
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
 
Format application/pdf
 
Identifier http://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/359
 
Source Iraqi Journal of Pharmaceutical Sciences ( P-ISSN: 1683 - 3597 , E-ISSN : 2521 - 3512); Vol 25 No 1 (2016): Iraqi J Pharm Sci, Vol.25(1) 2016; 42-49
1683-3597
2521-3512
 
Language eng
 
Relation http://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/359/293
 
Rights Copyright (c) 2017 Iraqi Journal of Pharmaceutical Sciences