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Preparation and Characterization of Montelukast Sodium ( SMLT ) as a Dual Sustained Release Buccal Strips

Iraqi Journal of Pharmaceutical Sciences

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Title Preparation and Characterization of Montelukast Sodium ( SMLT ) as a Dual Sustained Release Buccal Strips
Creator I.Khalil, Yehia
Description An oral bi layer  sustained release (SR) strips of Sodium  Montelukast SMLT , which is selective  leukotriene  antagonist  , used  for  patients  suffered from mid-night asthma , were prepared successfully ,using different polymers, like guar  gum , carrageenan , and xanthan gum , by solvent casting method .
The results obtained by this study revealed  ,that best  fast  dissolving  film of  SMLT was  loaded  in carrageenan   polymer 57%  w\w (30mg.) ,  with  acceptable  physical properties, like film thickness , elastic endurance and  surface pH  .
Besides  to that , the  disintegration  time , and  cumulative  80%   drug  release  were estimated  22 seconds and 3.7 minutes , respectively .On the other hand , the sustained release film ( FSR6-7 )  as a second layer , appear to be the most promised  layer of SMLT loaded in 50 % w\w  (15mg.) PVP K17 , with respect to its film thickness, elastic endurance and , surface pH .
Moreover the , the disintegration time of the second layer film was 21seconds , and the time for 50% drug release  was 15 minutes  extended  for 4hours of 100% drug release .
Meanwhile , the  investigation of possible  interference  between the  drug , and, polymers used  revealed  no evidence of this effect ,using FTIR  , and SEM  technique . In an attempt to evaluate the extended release effect of the selected formula , Singulair® plain tablet  as a marketed product was used , the result gave  more  than 4 hours  of  selected formula , compared with  30 minutes to marketed product Singulair® .
The overall results candidates  the selected  FSR6-7  formula  as a promised  bi layer buccal fast , as compliance  and  extended therapy for asthmatic mid- night patients.
Keywords: Montelukast sodium, Dual buccal  strips, Guar gum, Xanthan gum, Carrageenan.
Publisher University of Baghdad- College of Pharmacy
Date 2017-03-26
Type info:eu-repo/semantics/article
Format application/pdf
Source Iraqi Journal of Pharmaceutical Sciences ( P-ISSN: 1683 - 3597 , E-ISSN : 2521 - 3512); Vol 24 No 2 (2015): Iraqi J Pharm Sci, Vol.24(2) 2015; 61-71
Language eng
Rights Copyright (c) 2017 Iraqi Journal of Pharmaceutical Sciences