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Preparation, Characterization and Prophylactic Study of New Microsphere Containing Doxycycline against Diseases of Shrimp

Iraqi Journal of Pharmaceutical Sciences

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Title Preparation, Characterization and Prophylactic Study of New Microsphere Containing Doxycycline against Diseases of Shrimp
 
Creator J. Mehsin, Raheem
A.Raheem, Leaqaa
H. Ghazi, Abdulhussein
A.Khathem, Saba
 
Description Therapeutically and prophylactically using Microspheres containing doxycycline isolated from shell of shrimp. Low molecule weight poly lactic acid was prepared. In this study, Poly lactic acid (PLA)/ poly vinyl alcohol (PVA)/poly ethyleneglycol(PEG) loading doxycycline blend solutions was prepared. Also Poly lactic acid (PLA)-Tannin blend via solvent evaporation method was prepared. Microspheres of chitosan/gelatin microsphere loading doxycycline was prepared by emulsion crosslinking technique. Both microsphere and blends were characterized by Fourier transform infrared (FTIR) spectrophotometer. The FTIR spectra were shown distinguish bands. The in vitro release of doxcycline from its matrix at pH 7 was studied. The prophylactic against white spot (Ich) disease of shrimp (Macrobrachium nipponense) was studied. The results were shown increase of percentage of survival of shrimp in both microsphere and blend compared with control. The highly percentage of survival was shown in the microsphere compare with blends.
Key words: Chitosan, Microsphere, Polymer blend, Shrimp, Prophylactic.
 
 
Publisher University of Baghdad- College of Pharmacy
 
Date 2017-03-27
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
 
Format application/pdf
 
Identifier http://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/376
 
Source Iraqi Journal of Pharmaceutical Sciences ( P-ISSN: 1683 - 3597 , E-ISSN : 2521 - 3512); Vol 24 No 1 (2015): Iraqi J Pharm Sci, Vol.24(1) 2015; 33-39
1683-3597
2521-3512
 
Language eng
 
Relation http://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/376/309
 
Rights Copyright (c) 2017 Iraqi Journal of Pharmaceutical Sciences