Spectrophotometric Determination of Chlordiazepoxide in Pharmaceutical Formulations via Oxidative Coupling Reaction with Phenothiazine
Iraqi Journal of Pharmaceutical Sciences
View Archive Info| Field | Value | |
| Title |
Spectrophotometric Determination of Chlordiazepoxide in Pharmaceutical Formulations via Oxidative Coupling Reaction with Phenothiazine
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| Creator |
J. Ahmed, Mariam
Abdullah, hind H. |
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| Description |
Abstract A sensitive, precise and reliable indirect spectrophotometric method for the determination of chlordiazepoxide (CDE) in pure and pharmaceutical dosage forms is described. The method is based on oxidative coupling reaction between amino group resulting from acidic decomposition of CDE with phenothiazine in the presence of sodium periodate to produce an intense green soluble dye that is stable and shows a maximum absorption at 602 nm. The calibration plot indicates that Beer’s law is obeyed over the concentration range of 0.1?50 µg/mL, with a molar absorptivity of 1×104 L/mol cm and correlation coefficient of 0.9994.All the conditions that affecting on the stability and sensitivity of the formed product were studied and optimized and the suggested method was effectively applied for the determination of CDE in commercial dosage forms. |
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| Publisher |
University of Baghdad- College of Pharmacy
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| Date |
2018-12-05
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| Type |
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion |
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| Format |
application/pdf
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| Identifier |
http://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/761
10.31351/vol27iss2pp7-14 |
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| Source |
Iraqi Journal of Pharmaceutical Sciences ( P-ISSN: 1683 - 3597 , E-ISSN : 2521 - 3512); Vol 27 No 2 (2018): Iraqi J Pharm Sci; 7-14
1683-3597 2521-3512 |
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| Language |
eng
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| Relation |
http://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/761/705
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| Rights |
Copyright (c) 2018 Iraqi Journal of Pharmaceutical Sciences ( P-ISSN: 1683 - 3597 , E-ISSN : 2521 - 3512)
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