Dissolution Enhancement of Raltegravir by Hot Melt Extrusion Technique
Iraqi Journal of Pharmaceutical Sciences
View Archive Info| Field | Value | |
| Title |
Dissolution Enhancement of Raltegravir by Hot Melt Extrusion Technique
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| Creator |
S. Abdul Jabbar, Ahmed
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| Description |
The objective of the study to develop an amorphous solid dispersion for poorly soluble raltegravir by hot melt extrusion (HME) technique. A novel solubility improving agent plasdone s630 was utilized. The HME raltegravir was formulated into tablet by direct compression method. The prepared tablets were assessed for all pre and post-compression parameters. The drug- excipients interaction was examined by FTIR and DSC. All formulas displayed complying with pharmacopoeial measures. The study reveals that formula prepared by utilizing drug and plasdone S630 at 1:1.5 proportion and span 20 at concentration about 30mg (trail-6) has given highest dissolution rate than contrasted with various formulas of raltegravir. Keywords: Hot melt extrusion, Raltegravir, Plasdone S630. |
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| Publisher |
University of Baghdad- College of Pharmacy
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| Date |
2018-06-04
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| Type |
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion |
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| Format |
application/pdf
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| Identifier |
http://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/768
10.31351/vol27iss1pp20-29A |
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| Source |
Iraqi Journal of Pharmaceutical Sciences ( P-ISSN: 1683 - 3597 , E-ISSN : 2521 - 3512); Vol 27 No 1 (2018): Iraqi J Pharm Sci; 20-29A
1683-3597 2521-3512 |
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| Language |
eng
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| Relation |
http://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/768/648
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| Rights |
Copyright (c) 2018 Iraqi Journal of Pharmaceutical Sciences ( P-ISSN: 1683 - 3597 , E-ISSN : 2521 - 3512)
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